Press Release

CAMBRIDGE, Mass., Jun 08, 2009 (BUSINESS WIRE) -- Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) announced today that additional holders of its 4.75% Convertible Senior Subordinated Notes due 2013 have agreed to exchange approximately $40.2 million in aggregate principal amount of those notes for approximately 1.9 million shares of the Company's common stock, which is approximately 112,000 shares more than the number of shares into which the notes were convertible under their original terms. The additional shares largely relate to unpaid interest through February 2010, when the notes would have been callable by the Company. Added to the agreements to exchange $103.3 million in aggregate principal amount announced earlier today, this brings the total amount of notes to be exchanged to $143.5 million.

The Company anticipates that these additional note exchanges will be completed by the close of business on June 11, 2009. Upon completion of the exchanges, the aggregate principal amount of the Company's 4.75% Convertible Senior Subordinated Notes due 2013 will be reduced to approximately $144.0 million. Upon issuance of the common stock in exchange for the notes, the Company will have approximately 180 million shares of common stock outstanding.

This announcement is neither an offer to exchange nor a solicitation of an offer to exchange any of these securities. The exchanges are exempt from registration under Section 3(a)(9) of the Securities Act of 1933.

About Vertex

Vertex Pharmaceuticals Incorporated is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for serious diseases. The Company's strategy is to commercialize its products both independently and in collaboration with major pharmaceutical companies. Vertex's product pipeline is focused on viral diseases, cystic fibrosis, inflammation, autoimmune diseases, cancer and pain. Vertex co-discovered the HIV protease inhibitor, Lexiva, with GlaxoSmithKline.

Lexivais a registered trademark of the GlaxoSmithKline group of companies.

Safe Harbor Statement

This press release contains forward-looking statements, including the statement that Vertex expects to close the exchanges by June 11, 2009. While the Company believes the forward-looking statements contained in this press release are accurate, those statements are subject to risks and uncertainties that could cause our results to vary materially. Those risks and uncertainties include the risk and uncertainty that the closing will not occur in a timely manner and other risks and uncertainties listed under Risk Factors in Vertex's annual report and quarterly reports filed with the Securities and Exchange Commission. Vertex disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise, unless required by law.

Vertex's press releases are available at www.vrtx.com

(VRTX-GEN)

SOURCE: Vertex Pharmaceuticals Incorporated

Vertex Pharmaceuticals Incorporated
Michael Partridge, 617-444-6108
Vice President, Investor Relations
or
Lora Pike, 617-444-6755
Associate Director, Investor Relations

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