Press Release

CAMBRIDGE, Mass., Nov 26, 2008 (BUSINESS WIRE) --

Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced that it will webcast its presentation at the Piper Jaffray 20^th Annual Health Care Conference on Tuesday, December 2, 2008 at 10:30 a.m. EST and at the NASDAQ OMX 22^nd Investor Program on Thursday, December 4, 2008 at 2:15 p.m. GST (9:15 a.m. EST).

The presentations will be webcast live and may be accessed from 'Events & Presentations' on the home page of Vertex's website at www.vrtx.com. A replay of the webcasts will also be available on the Company's website for two weeks following the presentation. To ensure a timely connection, it is recommended that users register at least 15 minutes prior to the scheduled webcast.

About Vertex

Vertex Pharmaceuticals Incorporated is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for serious diseases. The Company's strategy is to commercialize its products both independently and in collaboration with major pharmaceutical companies. Vertex's product pipeline is focused on viral diseases, inflammation, autoimmune diseases, cancer, pain and cystic fibrosis. Vertex co-discovered the HIV protease inhibitor, Lexiva, with GlaxoSmithKline.

Lexiva is a registered trademark of the GlaxoSmithKline group of companies.

Vertex's press releases are available at www.vrtx.com.

(VRTX-WEB)

SOURCE: Vertex Pharmaceuticals Incorporated

Vertex Pharmaceuticals Incorporated
Lora Pike, 617-444-6755
Manager, Investor Relations

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