Press Release

CAMBRIDGE, Mass., Nov 06, 2008 (BUSINESS WIRE) -- Vertex Pharmaceuticals Incorporated (Nasdaq: VRTX) today announced that it will webcast its presentation at Deutsche Bank's 2008 Biotech Boston Confab on Tuesday, November 11, 2008 and at the Credit Suisse 2008 Healthcare Conference on Thursday, November 13, 2008.

Joshua Boger, Ph.D., President and Chief Executive Officer of Vertex, will present at Deutsche Bank's 2008 Biotech Boston Confab. Vertex's presentation will be conducted on Tuesday, November 11, 2008 at 3:25 p.m. EST.

Ian Smith, Executive Vice President and Chief Financial Officer of Vertex, will present at the Credit Suisse 2008 Healthcare Conference. The presentation will be conducted on Thursday, November 13, 2008 at 10:00 a.m. MST (12:00 p.m. EST).

The presentations will be webcast live and may be accessed from 'Events & Presentations' on the home page of Vertex's website at www.vrtx.com. A replay of the webcasts will also be available on the Company's website for two weeks following the presentations. To ensure a timely connection, it is recommended that users register at least 15 minutes prior to the scheduled webcast.

About Vertex

Vertex Pharmaceuticals Incorporated is a global biotechnology company committed to the discovery and development of breakthrough small molecule drugs for serious diseases. The Company's strategy is to commercialize its products both independently and in collaboration with major pharmaceutical companies. Vertex's product pipeline is focused on viral diseases, inflammation, autoimmune diseases, cancer, pain and cystic fibrosis. Vertex co-discovered the HIV protease inhibitor, Lexiva, with GlaxoSmithKline.

Lexiva is a registered trademark of the GlaxoSmithKline group of companies.

Vertex's press releases are available at www.vrtx.com.

(VRTX-WEB)

SOURCE: Vertex Pharmaceuticals Incorporated

Vertex Pharmaceuticals Incorporated 
Lora Pike, 617-444-6755 
Manager, Investor Relations

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